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Article

Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels.

Circulation research - 16 May 2003

Wong Wai-man R, Hawe Emma, Li Lai K, Miller George J, Nicaud Viviane, Pennacchio Len A, Humphries Steve E, Talmud Philippa J

Abstract excerpt

The impact of common variants in the apolipoprotein gene cluster (APOC3-A4-A5) on prospective coronary heart disease (CHD) risk was examined in healthy UK men. Of the 2808 men followed over 9 years, 187 had a clinically defined CHD event. Examination of 9 single nucleotide polymorphisms (SNPs) in this group revealed that homozygotes for APOA4 S347 had significantly increased risk of CHD [hazard ratio (HR) of 2.07...

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Source

Identifiers

PMID: 12676816
DOI: 10.1161/01.RES.0000069688.94567.7A

Genes

APOA4
APOC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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