Article
EphB4 receptor tyrosine kinase transgenic mice develop glomerulopathies reminiscent of aglomerular vascular shunts.
Mechanisms of development - 1 Apr 2003
Andres Anne-Catherine, Munarini Nadia, Djonov Valentin, Bruneau Salomé, Zuercher Gisela, Loercher Saemi, Rohrbach Valeria, Ziemiecki Andrew
Abstract excerpt
We have established transgenic mice over-expressing the EphB4 receptor tyrosine kinase in the kidney. The EphB4 protein was localised to the developing tubular system of both control and transgenic newborn mice. In transgenic adults, transgene expression persisted in the proximal tubules and the Bowman's capsules, structures, which were not stained in control kidneys. The glomeruli of control animals consisted of...
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