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Article

Mice with altered alpha-actinin-4 expression have distinct morphologic patterns of glomerular disease.

Kidney international - 1 Mar 2008

Henderson J M, Al-Waheeb S, Weins A, Dandapani S V, Pollak M R

Abstract excerpt

Mutations in ACTN4, encoding the actin-binding protein alpha-actinin-4, cause a form of familial focal segmental glomerulosclerosis. We had developed two strains of transgenic mice with distinct alterations in the expression of alpha-actinin-4. One strain carried a human disease-associated mutation in murine Actn4, whereas the other knockout strain did not express alpha-actinin-4 protein. Most adult homozygous...

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Source

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Identifiers

PMID: 18185509
DOI: 10.1038/sj.ki.5002751
PMCID: PMC2980842

Genes

ACTN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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