Article
Robustness of inference of haplotype block structure.
Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2003
Schwartz Russell, Halldórsson Bjarni V, Bafna Vineet, Clark Andrew G, Istrail Sorin
Abstract excerpt
In this report, we examine the validity of the haplotype block concept by comparing block decompositions derived from public data sets by variants of several leading methods of block detection. We first develop a statistical method for assessing the concordance of two block decompositions. We then assess the robustness of inferred haplotype blocks to the specific detection method chosen, to arbitrary choices made...
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