Article
Impact of aging upon DBA/2J B cells.
Immunobiology - 1 Jan 2003
Howell Koko F, Campo Melissa F, Mahjied Tazee, Coleman Clenton, Prokopenko Nataliya, Riggs James E
Abstract excerpt
The influence of age on B lymphocyte phenotype and function in DBA/2J mice was examined. The B cells of this strain express the endogenous minor lymphocyte stimulatory (Mls) retroviral superantigen (SAg) Mls-1a permitting assessment of age-related changes in cognate B cell-T cell interaction. Relative to young DBA/2J mice (< 8 months), old mice (> 17 months) had greater numbers of B cells expressing high levels...
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