Effect of alpha-globin genotype on the pathophysiology of sickle cell disease.

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Article

Effect of alpha-globin genotype on the pathophysiology of sickle cell disease.

Pediatric pathology & molecular medicine - 1 Jan 2000

Ballas S K

Abstract excerpt

The clinical picture of sickle cell disease is heterogeneous and varies tremendously among patients and in the same patient from time to time. The level of HbF, alpha-genotype, beta-haplotype, age, sex, and the environment are important factors that modify the clinical picture of sickle cell disease. My paper focuses on the effect of alpha-globin genotype on the pathophysiology of sickle cell anemia, HbSC...

Topics

Adult
Anemia, Sickle Cell
Ethnicity
Female
Gene Expression Regulation
Genotype
Globins
Hemoglobin SC Disease
Hemorheology
Humans
Male
Middle Aged
Sequence Deletion
alpha-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 12673836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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