Germ line variants in patients with acute myeloid leukemia without a suspicion of hereditary hematologic malignancy syndrome.

doi:10.1182/bloodadvances.2023009742

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Article

Germ line variants in patients with acute myeloid leukemia without a suspicion of hereditary hematologic malignancy syndrome.

Blood advances - 10 Oct 2023

Guijarro Francesca, López-Guerra Monica, Morata Jordi, Bataller Alex, Paz Sara, Cornet-Masana Josep Maria, Banús-Mulet Antònia, Cuesta-Casanovas Laia, Carbó Josep Maria, Castaño-Díez Sandra, Jiménez-Vicente Carlos, Cortés-Bullich Albert, Triguero Ana, Martínez-Roca Alexandra, Esteban Daniel, Gómez-Hernando Marta, Álamo Moreno José Ramón, López-Oreja Irene, Garrote Marta, Risueño Ruth M, Tonda Raúl, Gut Ivo, Colomer Dolors, Díaz-Beya Marina, Esteve Jordi

Abstract excerpt

Germ line predisposition in acute myeloid leukemia (AML) has gained attention in recent years because of a nonnegligible frequency and an impact on management of patients and their relatives. Risk alleles for AML development may be present in patients without a clinical suspicion of hereditary hematologic malignancy syndrome. In this study we investigated the presence of germ line variants (GVs) in 288 genes...

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Identifiers

PMID: 37450374
DOI: 10.1182/bloodadvances.2023009742
PMCID: PMC10561046

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