Article
VIPase autoantibodies in Fas-defective mice and patients with autoimmune disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2003
Bangale Yogesh, Karle Sangeeta, Planque Stephanie, Zhou Yong-Xin, Taguchi Hiroaki, Nishiyama Yasuhiro, Li Lan, Kalaga Ravishankar, Paul Sudhir
Abstract excerpt
The immunoregulatory neuropeptide vasoactive intestinal peptide (VIP) was cleaved by purified IgG from Fas-defective C3H/gld mice, lupus patients, and autoimmune thyroiditis patients. No VIPase activity was detected in IgG from control mice and humans. Kinetic analyses of VIPase IgG preparations suggested low-affinity recognition of VIP. Yet the VIPase activity was VIP selective, judged by lack of correlation...
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