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Switching Species Tropism: an Effective Way To Manipulate the Feline Coronavirus Genome

27 Mar 2003

Abstract excerpt

Feline infectious peritonitis virus (FIPV), a coronavirus, is the causative agent of an invariably lethal infection in cats. Like other coronaviruses, FIPV contains an extremely large positive-strand RNA genome of ca. 30 kb. We describe here the development and use of a reverse genetics strategy for FIPV based on targeted RNA recombination that is analogous to what has been described for the mouse hepatitis virus...

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PMID: 12663759
DOI: 10.1128/jvi.77.8.4528-4538.2003

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