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Article

Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites

31 Mar 2003

Abstract excerpt

Monocyte-derived dendritic cells (DCs) and macrophages (Ms) generated in vitro from the same individual blood donors were exposed to 5 different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, Leishmania donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were...

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PMID: 12663451
DOI: 10.1182/blood-2002-10-3232

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