Article
FAS gene mutation in a case of autoimmune lymphoproliferative syndrome type IA with accumulation of gammadelta+ T cells.
The American journal of surgical pathology - 1 Apr 2003
van den Berg Anke, Tamminga Rienk, de Jong Debora, Maggio Ewerton, Kamps Willem, Poppema Sibrand
Abstract excerpt
A 6-month-old girl presented to the hospital with cervical lymphadenopathy and hepatosplenomegaly. She was known to have an enlarged spleen, anemia, and thrombocytopenia since the age of 1 month. A lymph node biopsy showed a diffuse proliferation of blasts with few remnants of follicles. The blasts were CD3+CD57+CD4-CD8-, consistent with the usual autoimmune lymphoproliferative syndrome phenotype. However, these...
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