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Article

The role of genomics in antimicrobial discovery

13 Mar 2003

Abstract excerpt

The majority of today’s most effective classes of antimicrobials originated many decades ago as natural products isolated from soil-colonizing bacteria and fungi. Several of these antibiotics were amenable to semi-synthetic chemistry, and as a result the antimicrobial industry has excelled at fine-tuning these existing classes of antibiotics to improve their spectrum, efficacy and safety. Conversely, there are...

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PMID: 12654742
DOI: 10.1093/jac/dkg178

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