Article
Harnessing the Power of the Genome in the Search for New Antibiotics
17 Mar 2000
Abstract excerpt
Over the past 40 years, the search for new antibiotics has been largely restricted to well-known compound classes active against a standard set of drug targets. Although many effective compounds have been discovered, insufficient chemical variability has been generated to prevent a serious escalation in clinical resistance. Recent advances in genomics have provided an opportunity to expand the range of potential...
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