Article
p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer.
Gynecologic oncology - 1 Mar 2003
Okuda Tsuyoshi, Otsuka Junko, Sekizawa Akihiko, Saito Hiroshi, Makino Reiko, Kushima Miki, Farina Antonio, Kuwano Yuzuru, Okai Takashi
Abstract excerpt
OBJECTIVE: Although ovarian clear cell adenocarcinoma (OCCA) and ovarian endometrioid adenocarcinoma (EC) are considered to be closely related to endometriosis, the mechanisms of carcinogenesis of these two malignancies and malignant transformation of endometriosis are unclear. In this study, we examined the biology of OCCA and EC by performing large-scale analysis of K-ras activation and p53 mutation and...
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