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Article

Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm.

Human pathology - 1 Jul 2011

Kurman Robert J, Shih Ie-Ming

Abstract excerpt

Recent morphologic, immunohistochemical, and molecular genetic studies have led to the development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer based on a dualistic model of carcinogenesis that divides epithelial ovarian cancer into 2 broad categories designated types I and II. Type I tumors comprise low-grade serous, low-grade endometrioid, clear cell and mucinous carcinomas,...

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Share to Carcinoma, Ovarian Epithelial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Glandular and Epithelial

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Source

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Identifiers

PMID: 21683865
DOI: 10.1016/j.humpath.2011.03.003
PMCID: PMC3148026

Genes

BRAF
CTNNB1
ERBB2
KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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