Article
A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice.
Developmental biology - 15 Mar 2003
Beck Felix, Chawengsaksophak Kallayanee, Luckett Jenni, Giblett Susan, Tucci Joseph, Brown Jane, Poulsom Richard, Jeffery Rosemary, Wright Nicholas A
Abstract excerpt
Inactivation of Cdx2 by homologous recombination results in the development of forestomach epithelium at ectopic sites in pericaecal areas of the midgut of heterozygote mice. Local factors subsequently result in the secondary induction of tissues exhibiting an orderly sequence of tissue types between the ectopic forestomach tissue and the surrounding colon. Clonal analysis of this secondarily generated tissue...
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