Article
Increased frequency of the mannose-binding lectin LX haplotype in Chinese systemic lupus erythematosus patients.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Apr 2003
Huang Y F, Wang W, Han J Y, Wu X W, Zhang S T, Liu C J, Hu Q G, Xiong P, Hamvas R M J, Wood N, Gong F L, Bittles A H
Abstract excerpt
Mannose-binding lectin (MBL) is an important complement-activating protein of the human immune system. As a result of one of three structural gene mutations in exon 1 (variants B, C and D) and/or the presence of a low-efficiency promoter polymorphism, MBL deficiency may be associated with increased susceptibility to infectious diseases and to autoimmune disorders, including systemic lupus erythematosus (SLE)....
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