Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A model system for increased meiotic nondisjunction in older oocytes.

Current biology : CB - 18 Mar 2003

Jeffreys Charlotte A, Burrage Peter S, Bickel Sharon E

Abstract excerpt

For at least 5% of all clinically recognized human pregnancies, meiotic segregation errors give rise to zygotes with the wrong number of chromosomes. Although most aneuploid fetuses perish in utero, trisomy in liveborns is the leading cause of mental retardation. A large percentage of human trisomies originate from segregation errors during female meiosis I; such errors increase in frequency with maternal age....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Drosophila melanogaster
Share to Meiosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Nondisjunction, Genetic

Share to Oocytes

Share to Recombination, Genetic

Share to X Chromosome

Source

Identifiers

PMID: 12646133
DOI: 10.1016/s0960-9822(03)00134-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A model system for increased meiotic nondisjunction in older oocytes.PMID 12646133Read ↗

Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced.Semantic proximity Read ↗

Increased levels of superoxide dismutase suppress meiotic segregation errors in aging oocytesSemantic proximity Read ↗

Rejuvenation of Meiotic Cohesion in Oocytes during Prophase I Is Required for Chiasma Maintenance and Accurate Chromosome SegregationSemantic proximity Read ↗

Human aneuploidy: lessons from achiasmate segregation in Drosophila melanogaster.Semantic proximity Read ↗

Bivalent separation into univalents precedes age-related meiosis I errors in oocytesSemantic proximity Read ↗

Oocyte ageing and its cellular basisSemantic proximity Read ↗

Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errorsSemantic proximity Read ↗

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errorsSemantic proximity Read ↗

New Insights into the Genetic Regulation of Homologue Disjunction in Mammalian OocytesSemantic proximity Read ↗

Aging Negatively Impacts DNA Repair and Bivalent Formation in the C. elegans Germ LineSemantic proximity Read ↗

Age‐dependent aneuploidy in mammalian oocytes instigated at the second meiotic divisionSemantic proximity Read ↗

Analysis of chromosome behavior in intact mammalian oocytes: monitoring the segregation of a univalent chromosome during female meiosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.