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Article

Budding yeast PAK kinases regulate mitotic exit by two different mechanisms.

The Journal of cell biology - 17 Mar 2003

Chiroli Elena, Fraschini Roberta, Beretta Alessia, Tonelli Mariagrazia, Lucchini Giovanna, Piatti Simonetta

Abstract excerpt

We report the characterization of the dominant-negative CLA4t allele of the budding yeast CLA4 gene, encoding a member of the p21-activated kinase (PAK) family of protein kinases, which, together with its homologue STE20, plays an essential role in promoting budding and cytokinesis. Overproduction of the Cla4t protein likely inhibits both endogenous Cla4 and Ste20 and causes a delay in the onset of anaphase that...

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PMID: 12642613
DOI: 10.1083/jcb.200209097
PMCID: PMC2173773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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