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Article

The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation.

Journal of molecular biology - 28 Mar 2003

Heikinheimo Pirkko, Helland Ronny, Leiros Hanna-Kirsti Schrøder, Leiros Ingar, Karlsen Solveig, Evjen Gry, Ravelli Raimond, Schoehn Guy, Ruigrok Rob, Tollersrud Ole Kristian, McSweeney Seán, Hough Edward

Abstract excerpt

Lysosomal alpha-mannosidase (LAM: EC 3.2.1.24) belongs to the sequence-based glycoside hydrolase family 38 (GH38). Two other mammalian GH38 members, Golgi alpha-mannosidase II (GIIAM) and cytosolic alpha-mannosidase, are expressed in all tissues. In humans, cattle, cat and guinea pig, lack of lysosomal alpha-mannosidase activity causes the autosomal recessive disease alpha-mannosidosis. Here, we describe the...

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PMID: 12634058
DOI: 10.1016/s0022-2836(03)00172-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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