Article
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis.
Molecular biology of the cell - 1 Mar 2003
Pomorski Thomas, Lombardi Ruben, Riezman Howard, Devaux Philippe F, van Meer Gerrit, Holthuis Joost C M
Abstract excerpt
Plasma membranes in eukaryotic cells display asymmetric lipid distributions with aminophospholipids concentrated in the inner and sphingolipids in the outer leaflet. This asymmetry is maintained by ATP-driven lipid transporters whose identities are unknown. The yeast plasma membrane contains two P-type ATPases, Dnf1p and Dnf2p, with structural similarity to ATPase II, a candidate aminophospholipid translocase...
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