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Article

Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse.

The pharmacogenomics journal - 1 Jan 2003

Lehrmann E, Oyler J, Vawter M P, Hyde T M, Kolachana B, Kleinman J E, Huestis M A, Becker K G, Freed W J

Abstract excerpt

CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of age- and post-mortem interval-matched male cocaine abusers and controls. The presence of cocaine and related metabolites was confirmed by gas chromatography-mass spectrometry. Sixty-five transcripts were differentially expressed, indicating alterations in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12629581
DOI: 10.1038/sj.tpj.6500146
PMCID: PMC1907635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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