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Bone Marrow–Derived Cardiomyocytes Are Present in Adult Human Heart

10 Mar 2003

Abstract excerpt

BACKGROUND: Recent studies have identified cardiomyocytes of extracardiac origin in transplanted human hearts, but the exact origin of these myocyte progenitors is currently unknown. METHODS AND RESULTS: Hearts of female subjects (n=4) who had undergone sex-mismatched bone marrow transplantation (BMT) were recovered at autopsy and analyzed for the presence of Y chromosome-positive cardiomyocytes. Four female...

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PMID: 12628942
DOI: 10.1161/01.cir.0000061910.39145.f0

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