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Article

Intrinsic cardiac origin of human cardiosphere-derived cells

9 Jun 2011

Abstract excerpt

AIMS: Cardiosphere-derived cells (CDCs) are in clinical development as a regenerative cell product which can be expanded ex vivo from patient cardiac biopsies. Cardiosphere-derived cells are clonogenic, exhibit multilineage differentiation, and exert functional benefits in preclinical models of heart failure. The origin of CDCs remains unclear: are these cells endogenous to the heart, or do they arise from cells...

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PMID: 21659438
DOI: 10.1093/eurheartj/ehr172

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