Article
A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients.
Journal of the American College of Cardiology - 5 Mar 2003
Konno Tetsuo, Shimizu Masami, Ino Hidekazu, Matsuyama Toru, Yamaguchi Masato, Terai Hidenobu, Hayashi Kenshi, Mabuchi Tomohito, Kiyama Masaru, Sakata Kenji, Hayashi Tatsumi, Inoue Masaru, Kaneda Tomoya, Mabuchi Hiroshi
Abstract excerpt
OBJECTIVES: We studied the clinical features of hypertrophic cardiomyopathy (HCM) caused by a novel mutation in the myosin binding protein-C (MyBP-C) gene in patients and family members of Japanese descent. BACKGROUND: Previous reports have demonstrated that the clinical features of HCM associated with mutations in the MyBP-C gene include late onset and a favorable clinical course. Recently, some mutations in...
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