Article
Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy.
The New England journal of medicine - 30 Apr 1998
Niimura H, Bachinski L L, Sangwatanaroj S, Watkins H, Chudley A E, McKenna W, Kristinsson A, Roberts R, Sole M, Maron B J, Seidman J G, Seidman C E
Abstract excerpt
BACKGROUND: Mutations in the gene for cardiac myosin-binding protein C account for approximately 15 percent of cases of familial hypertrophic cardiomyopathy. The spectrum of disease-causing mutations and the associated clinical features of these gene defects are unknown. METHODS: DNA sequences en...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Cardiomyopathy, Hypertrophic
- Carrier Proteins
- Child
- DNA Mutational Analysis
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Mutation