Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia.

doi:10.1002/ajmg.b.10053

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Article

Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2003

Iwayama-Shigeno Yoshimi, Yamada Kazuo, Toyota Tomoko, Shimizu Hiromitsu, Hattori Eiji, Yoshitsugu Kiyoshi, Fujisawa Tetsuya, Yoshida Yukako, Kobayashi Toshio, Toru Michio, Kurumaji Akeo, Detera-Wadleigh Sevilla, Yoshikawa Takeo

Abstract excerpt

Dysregulation in dopaminergic neurotransmission might play a role in the pathogenesis of schizophrenia, and therefore genetic components of the dopamine (DA) pathway may confer risk. The NR4A2 (Nurr1) gene is essential for the development and maintenance of mesencephalic DA-synthesizing neurons. Moreover, Nurr1 forms a heterodimer with the retinoid X receptor and disturbances in the retinoid-signaling cascade may...

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PMID: 12627459
DOI: 10.1002/ajmg.b.10053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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