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Article

Mechanisms behind signet ring cell carcinoma formation.

Biochemical and biophysical research communications - 8 Aug 2014

Fukui Yasuhisa

Abstract excerpt

Signet ring cell carcinomas are highly malignant dedifferentiated adenocarcinomas. There are no cell-cell interactions between these round-shaped cells. They contain huge numbers of vacuoles, filled with mucins, which are secreted from the cells. The mechanism behind this phenotype has recently begun to be elucidated. In highly differentiated adenocarcinomas the ErbB2/ErbB3 complex is activated, which is followed...

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PMID: 25019985
DOI: 10.1016/j.bbrc.2014.07.025

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