Article
Analysis of mutations in alpha-actinin 4 and podocin genes of patients with chronic renal failure due to sporadic focal segmental glomerulosclerosis.
Renal failure - 1 Jan 2003
Komatsuda Atsushi, Wakui Hideki, Maki Nobuki, Kigawa Akihiro, Goto Hiroyuki, Ohtani Hiroshi, Hamai Keiko, Oyama Yuhta, Makoto Hirokawa, Sawada Ken-ichi, Imai Hirokazu
Abstract excerpt
Although the pathogenesis of idiopathic focal segmental glomerulosclerosis (FSGS) may be heterogeneous, autosomal dominant and recessive forms of FSGS are recognized. Recently, mutations in alpha-actinin 4 (ACTN4) and podocin genes were reported in patients with such familial FSGS. However, whether mutations in ACTN4 and podocin genes are associated with sporadic FSGS has not been determined. In the present...
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