Article
Molecular analysis of NPHS2 and ACTN4 genes in a series of 33 Italian patients affected by adult-onset nonfamilial focal segmental glomerulosclerosis.
Nephron. Clinical practice - 1 Jan 2005
Aucella Filippo, De Bonis Patrizia, Gatta Giuseppe, Muscarella Lucia Anna, Vigilante Mimmo, di Giorgio Giuseppe, D'Errico Michele, Zelante Leopoldo, Stallone Carmine, Bisceglia Luigi
Abstract excerpt
BACKGROUND: Mutations in the NPHS2 gene, encoding podocin, and in the ACTN4 gene, encoding alpha-actinin-4, have been identified in familial childhood-onset forms of focal and segmental glomerulosclerosis (FSGS). NPHS2 may be also responsible for some sporadic cases. The role of NPHS2 and ACTN4 in the adult sporadic form of the disease is being clarifying. METHODS: Thirty-three adult subjects affected by sporadic...
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