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Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase

1 Mar 2003

Abstract excerpt

To create immortal mesenchymal cell lines, we transduced primary human bone marrow mesenchymal cells with telomerase reverse transcriptase (TERT). TERT+ mesenchymal cells continued to grow for > 2 years; parallel TERT- cultures underwent senescence after 15 weeks. TERT+ mesenchymal cells did not form foci in soft agar, had a normal karyotype and could differentiate into osteoblasts and chondrocytes. Their...

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PMID: 12614220
DOI: 10.1046/j.1365-2141.2003.04217.x

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