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Article

3′ Nontranslated RNA Signals Required for Replication of Hepatitis C Virus RNA

27 Feb 2003

Abstract excerpt

We describe a mutational analysis of the 3' nontranslated RNA (3'NTR) signals required for replication of subgenomic hepatitis C virus (HCV) RNAs. A series of deletion mutants was constructed within the background of an HCV-N replicon that induces the expression of secreted alkaline phosphatase in order to examine the requirements for each of the three domains comprising the 3'NTR, namely, the highly conserved 3'...

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PMID: 12610131
DOI: 10.1128/jvi.77.6.3557-3568.2003

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