Article
Pathological analysis of muscle hypertrophy and degeneration in muscular dystrophy in gamma-sarcoglycan-deficient mice.
Neuromuscular disorders : NMD - 1 Mar 2003
Sasaoka Toshikuni, Imamura Michihiro, Araishi Kenji, Noguchi Satoru, Mizuno Yuji, Takagoshi Naomi, Hama Hiroshi, Wakabayashi-Takai Eriko, Yoshimoto-Matsuda Yukiko, Nonaka Ikuya, Kaneko Kiyotoshi, Yoshida Mikiharu, Ozawa Eijiro
Abstract excerpt
While calf muscle hypertrophy is a striking diagnostic finding in sarcoglycanopathy, as it is in Duchenne and Becker muscular dystrophies, its pathogenetic mechanism remains unknown. gamma-Sarcoglycan, one of the subunits of the sarcoglycan complex, is the protein responsible for gamma-sarcoglycanopathy. To elucidate the pathogenetic mechanisms of muscle hypertrophy and degeneration in muscular dystrophy, we...
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