The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE‐A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma

Abstract excerpt

AIMS: Spermatocytic seminoma is a rare germ cell derived tumour of the testis that occurs mainly in older men. We analysed the expression of recently discovered markers for germ cell differentiation and the mitosis-meiosis transition in order to define the antigen profile for diagnostic purposes and to clarify the biology and histogenesis of spermatocytic seminoma. METHODS AND RESULTS: Twenty-five spermatocytic...

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