Article
PAX4 mutation (R121W) as a prodiabetic variant in Okinawans.
Biochemical and biophysical research communications - 7 Mar 2003
Shimajiri Yoshinori, Shimabukuro Michio, Tomoyose Takeaki, Yogi Hiroyuki, Komiya Ichiro, Takasu Nobuyuki
Abstract excerpt
We previously reported that a missense mutation at codon 121 (CGG(Arg) to TGG(Trp), R121W) of PAX4 may be associated with the onset of type 2 diabetes in Japanese. In this study, we determined the frequency of the R121W mutation of PAX4 and characterized the prodiabetic phenotype in a population-based study. Healthy 372 residents participated in annual health check-ups in Nishihara (Okinawa, Japan) and unrelated...
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