Article
The purine salvage enzyme hypoxanthine guanine xanthine phosphoribosyl transferase is a major target antigen for cell-mediated immunity to malaria.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Makobongo Morris O, Riding George, Xu Huji, Hirunpetcharat Chakrit, Keough Dianne, de Jersey John, Willadsen Peter, Good Michael F
Abstract excerpt
Although there is good evidence that immunity to the blood stages of malaria parasites can be mediated by different effector components of the adaptive immune system, target antigens for a principal component, effector CD4(+) T cells, have never been defined. We generated CD4(+) T cell lines to fractions of native antigens from the blood stages of the rodent parasite, Plasmodium yoelii, and identified...
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