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Article

Polymorphisms beta2-glycoprotein I: phospholipid binding and multimeric structure.

Thrombosis research - 1 Nov 2002

Gushiken Francisca C, Le Anhqueyn, Arnett Frank C, Thiagarajan Perumal

Abstract excerpt

beta2-glycoprotein I is a phospholipid-binding protein of 326 amino acids and is found in plasma at a concentration of approximately 200 microg/ml. It has a sequence of positively charged amino acids located at the carboxy terminus that mediates anionic phospholipid binding. Two polymorphisms (306Cys-->Gly and 316Trp-->Ser) located at the phospholipid-binding site have been described. Homozygous state for either...

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PMID: 12590955
DOI: 10.1016/s0049-3848(02)00392-4

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