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Article

Differential changes in striatal projection neurons in R6/2 transgenic mice for Huntington's disease.

Neurobiology of disease - 1 Dec 2002

Sun Z, Del Mar N, Meade C, Goldowitz D, Reiner A

Abstract excerpt

In early adult-onset Huntington's disease (HD), enkephalinergic striatopallidal projection neurons show preferential loss, reduced preproenkephalin (PPE) expression in surviving striatopallidal neurons, and loss of fibers in their projection target area. We examined PPE and PPT (preprotachykinin) gene expression in striatal projection neurons and in striatal projection fibers immunoreactive for the PPE product...

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Identifiers

PMID: 12586547
DOI: 10.1006/nbdi.2002.0554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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