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Article

Selective loss of striatal preprotachykinin neurons in a phenocopy of Huntington's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2002

Richfield Eric K, Vonsattel Jean-Paul, MacDonald Marcy E, Sun ZhiQiang, Deng Yun-Ping P, Reiner Anton

Abstract excerpt

Phenocopies of Huntington's disease (HD) are individuals with a family history, clinical symptoms, and occasionally pathological evidence of HD but without an expanded CAG repeat within the HD gene. We report on an HD phenocopy with selective loss of preprotachykinin (PPT) neurons, dysfunction of surviving PPT neurons, preservation of preproenkephalin (PPE) neurons within the striatum, and greater loss of...

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PMID: 11921119
DOI: 10.1002/mds.10032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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