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Article

Phosphorylation induces subtle structural changes in SpoIIAA, a key regulator of sporulation.

The Biochemical journal - 15 May 2003

Clarkson Joanna, Campbell Iain D, Yudkin Michael D

Abstract excerpt

The phosphorylation state of SpoIIAA is a key factor in the regulation of sporulation in Bacillus subtilis. Previous crystallographic studies had led to the conclusion that phosphorylation alters the binding affinity of SpoIIAA for its partner proteins solely through the additional charge and bulk of the phosphoryl group: small structural changes observed elsewhere in the protein were considered to be random...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12585962
DOI: 10.1042/BJ20021748
PMCID: PMC1223372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation induces subtle structural changes in SpoIIAA, a key regulator of sporulation.PMID 12585962Read ↗

NMR studies of the interactions of SpoIIAA with its partner proteins that regulate sporulation in Bacillus subtilis.Semantic proximity Read ↗

Genotype, phenotype, and protein structure in a regulator of sporulation: effects of mutations in the spoIIAA gene of Bacillus subtilis.Semantic proximity Read ↗

Conformational changes of Spo0F along the phosphotransfer pathway.Semantic proximity Read ↗

Bacillus subtilis mutations that alter the pathway of phosphorylation of the anti-anti-sigmaF factor SpoIIAA lead to a Spo- phenotype.Semantic proximity Read ↗

Interaction surface of the Spo0A response regulator with the Spo0E phosphatase.Semantic proximity Read ↗

A genetic analysis of Spo0A structure and function.Semantic proximity Read ↗

Dimer form of phosphorylated Spo0A, a transcriptional regulator, stimulates the spo0F transcription at the initiation of sporulation in Bacillus subtilis.Semantic proximity Read ↗

SpoIIE governs the phosphorylation state of a protein regulating transcription factor sigma F during sporulation in Bacillus subtilis.Semantic proximity Read ↗

Crystal structure of a phosphatase-resistant mutant of sporulation response regulator Spo0F from Bacillus subtilis.Semantic proximity Read ↗

Rebuttal: conformational changes of Spo0F along the phosphotransfer pathway.Semantic proximity Read ↗

Studies of SpoIIAB mutant proteins elucidate the mechanisms that regulate the developmental transcription factor sigmaF in Bacillus subtilis.Semantic proximity Read ↗

In vivo phosphorylation of partner switching regulators correlates with stress transmission in the environmental signaling pathway of Bacillus subtilis.Semantic proximity Read ↗

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