Article
[Genetic tests in oncology practice with emphasis on the RET oncogene and VHL tumor suppressor gene].
Srpski arhiv za celokupno lekarstvo - 1 Jul 2002
Nesković Gorana, Stanojević Boban, Palmar Ivan, Dimitrijević Bogomir
Abstract excerpt
Molecular oncogenetics is the study of two distinct gene classes participating in the pathogenesis of malignant diseases: proto-oncogenes and tumour suppressors genes. Stepwise alterations in their structure are the basis of malignancy. Structural abnormalities range widely: gross genetic rearrangements including insertions, deletions, gene amplifications and single nucleotide deleotide deletions and...
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