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Article

Alloimmune neonatal neutropenia linked to anti-HNA-4a.

Transfusion medicine (Oxford, England) - 1 Feb 2003

Fung Y L, Pitcher L A, Willett J E, Reed C, Mison L, Bux J, Eiber G, Minchinton R M

Abstract excerpt

This is a novel case report of alloimmune neonatal neutropenia (ANN) linked to the neutrophil antibody anti-HNA-4a (MART). Since its discovery, the HNA-4a antigen has never been associated with any clinical neutropenia. A first-born neonate with respiratory distress was found to be severely neutropenic, because of ANN. The broad reactivity of the antibody together with its capture by CD11b and CD18 in monoclonal...

Topics

Antigen-Antibody Reactions
CD11b Antigen
CD18 Antigens
Family Health
Granulocytes
Humans
Infant, Newborn
Isoantigens
Male
Neutropenia
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Respiratory Distress Syndrome, Newborn

Sequence Analysis, DNA

Source

Identifiers

PMID: 12581454
DOI: 10.1046/j.1365-3148.2003.00413.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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