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Article

In vitro lipolysis by human pancreatic lipase is specifically abolished by its inactive forms.

Biochimica et biophysica acta - 21 Feb 2003

Miled N, Berti-Dupuis L, Riviere M, Carrière F, Verger R

Abstract excerpt

In human adults, the enzymatic hydrolysis of dietary fat along the digestive tract is sequentially catalyzed by two main enzymes, human gastric lipase (HGL) and human pancreatic lipase (HPL). Both a chemically inhibited form of HPL as well as an inactive HPL mutant with a glycine residue substituted for its catalytic serine were found to be strong inactivators of HPL activity. In the presence of bile salts, this...

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PMID: 12573254
DOI: 10.1016/s1570-9639(02)00537-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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