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Article

Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein.

Oncogene - 6 Feb 2003

Frese Kristopher K, Lee Siu Sylvia, Thomas Darby L, Latorre Isabel J, Weiss Robert S, Glaunsinger Britt A, Javier Ronald T

Abstract excerpt

While PDZ domain-containing proteins represent cellular targets for several different viral oncoproteins, including human papillomavirus E6, human T-cell leukemia virus type 1 Tax, and human adenovirus E4-ORF1, the functional consequences for such interactions have not been elucidated. Here we report that, at the plasma membrane of cells, the adenovirus E4-ORF1 oncoprotein selectively and potently stimulates...

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Identifiers

PMID: 12569363
DOI: 10.1038/sj.onc.1206151
PMCID: PMC3501958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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