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Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells

11 Mar 2003

Abstract excerpt

Single human bone marrow-derived mesodermal progenitor cells (MPCs) differentiate into osteoblasts, chondrocytes, adipocytes, myocytes, and endothelial cells. To identify genes involved in the commitment of MPCs to osteoblasts we examined the expressed gene profile of undifferentiated MPCs and MPCs induced to the osteoblast lineage for 1-7 days by cDNA microarray analysis. As expected, growth factor, hormone, and...

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PMID: 12631704
DOI: 10.1073/pnas.0532693100

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