Article
Angiotensin I-converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore.
Cancer research - 1 Feb 2003
Koh Woon-Puay, Yuan Jian-Min, Sun Can-Lan, van den Berg David, Seow Adeline, Lee Hin-Peng, Yu Mimi C
Abstract excerpt
Angiotensin II has been shown to have possible mitogenic and angiogenic effects in human cell lines and animal models of breast cancer. It is converted from its precursor to its active form by the angiotensin I-converting enzyme (ACE). A recent epidemiological study observed lower breast cancer incidence in female users of ACE inhibitors relative to nonusers with comparable cardiovascular conditions. To study the...
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