Article
Angiotensin-converting enzyme gene insertion/deletion polymorphism and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2005
González-Zuloeta Ladd Angela M, Arias Vásquez Alejandro, Sayed-Tabatabaei Fakhredin A, Coebergh J W, Hofman Albert, Njajou Omer, Stricker Bruno, van Duijn Cornelia
Abstract excerpt
BACKGROUND: The renin-angiotensin system plays an important role in homeostasis and lately, its main effector, angiotensin II, has been attributed with angiogenic and growth factor actions in the breast tissue. Previous studies have shown that the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene accounts for the variability of ACE plasma concentrations. The use of ACE...
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