Article
Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q.
American journal of human genetics - 1 Mar 2003
Slager S L, Schaid D J, Cunningham J M, McDonnell S K, Marks A F, Peterson B J, Hebbring S J, Anderson S, French A J, Thibodeau S N
Abstract excerpt
Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the...
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