Article
P27 knockout mice: reduced myostatin in muscle and altered adipogenesis.
Biochemical and biophysical research communications - 24 Jan 2003
Lin Ji, Della-Fera Mary Anne, Li Changlong, Page Karen, Choi Yang Ho, Hartzell Diane L, Baile Clifton A
Abstract excerpt
Knockout of the P27(kip) gene, which encodes a cyclin-dependent kinase inhibitor involved in cell proliferation regulation, results in growth enhancement in mice. To investigate how p27 deficiency affected adipogenesis and myogenesis, levels of PPARgamma, C/EBPalpha, and the myogenesis inhibitor, myostatin, were measured in p27(-/-) (n=14), p27(+/-) (n=18), and p27(+/+) mice (n=11). Body weight and gastrocnemius...
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