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Article

Acquired somatic mutations in the molecular pathogenesis of COPD.

Trends in pharmacological sciences - 1 Feb 2003

Anderson Gary P, Bozinovski Steven

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is caused mostly by cigarette smoking but its specific molecular mechanisms are obscure. Current theories suggest that the inflammation and oxidative stress induced by smoking lead to proteolytic imbalance and progressive lung structural derangement, with disease susceptibility being controlled by inherited variations in protective or inflammatory genes. However,...

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PMID: 12559770
DOI: 10.1016/S0165-6147(02)00052-4

Genes

EGFR
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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